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KMID : 0358319960370060646
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Korean Journal of Urology
1996 Volume.37 No. 6 p.646 ~ p.651
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The Clinical Value of the Serum and Urinary Levels of beta-HCG in Transitional Cell Carcinoma of the Bladder
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Abstract
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It has been reported that β-HCG is produced in the transitional cell carcinoma of the bladder and measuring of its level can be used as a tumor marker. We measured the serum and urinary levels of β-HCG in th atients with the transitional cell
carcinoma of the bladder and analysed the relationhip to the clinical stage and histological grade and its significance as a tumor marker. The levels of the β-HCG in the serum and dearly morning durine were measure in 40 cases of transitional
cell
carcinoma of the bladder and 37 cases of control group. Double-antibody immunometric assay (Coat-A-Count HCG IRMA) using 125I-labeled anti HCG antibody and monoclonal anti HCG antibody were used.
The mean levels of the serum and urinary β-HCG in control group were 1.2mIU/ml, 1.4mIU/ml and 3.6mIU/ml in paroup, which showed a statistically significant difference between the two groups(p<0.05). In patient group, the levels of the serum and
urinary
β-HCG were 2.9mIU/ml and 3.5mIU/ml in the superficial turmor, 2.6mIU/ml and 7.0mIU/ml in the invasive tumor and 7.5mIU/ml and 9.9mIU/ml in the medtastatic tumor, showing a statistically significant increase as the clinical stage was
addvanced(p<0.05).
the levels of the serum and urinary β-HCG were 3.3mIU/ml and 1.3mIU/ml in grade I, 2.9mIU/ml and 5.9mIU/ml in grade II and 4.7mIU/ml and 7.6mIU/ml in grade III, which did not demonstrate a significant relationship to the histological
graede(p>0.05).
We that the serum and urinary levels of β-HCG in the transitional cell carcinoma of the bladder are related to the tumor stage but not to the histological grade and in the metastatic tumor urinary β-HCG level can be used as a reliable tumor
marker.
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KEYWORD
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